Selected publications shown. For a complete list see Google Scholar
Loss of Predicted Cell Adhesion Molecule MPZL3 Promotes EMT in Ovarian Cancer. Cheng YY, Worley BL, Javed Z, Elhaw AT, Tang PW, Al-Saad S, Kamlapurkar S, White SR, Uboveja A, Mythreye K, Aird KM, Czyzyk TA, Hempel N. Cancer Res Commun. 2025 Jul 1;5(7):1180-1193. doi: 10.1158/2767-9764.CRC-24-0591. PMID: 40631617; PMCID: PMC12277487.
Crosstalk between calcium and reactive oxygen species signaling in cancer revisited. Cell Calcium. Pathak T, Benson JC, Tang PW, Trebak M, Hempel N. 2025 May;127:103014. doi: 10.1016/j.ceca.2025.103014. Epub 2025 Mar 18. PMID: 40139005; PMCID: PMC12579432.
Stress response regulation of mRNA translation: Implications for antioxidant enzyme expression in cancer. Kim YS, Kimball SR, Piskounova E, Begley TJ, Hempel N. Proc Natl Acad Sci U S A. 2024 Nov 12;121(46):e2317846121. doi: 10.1073/pnas.2317846121. Epub 2024 Nov 4. PMID: 39495917; PMCID: PMC11572934.
Drp1 splice variants regulate ovarian cancer mitochondrial dynamics and tumor progression. Javed Z, Shin DH, Pan W, White SR, Elhaw AT, Kim YS, Kamlapurkar S, Cheng YY, Benson JC, Abdelnaby AE, Phaëton R, Wang HG, Yang S, Sullivan MLG, St Croix CM, Watkins SC, Mullett SJ, Gelhaus SL, Lee N, Coffman LG, Aird KM, Trebak M, Mythreye K, Walter V, Hempel N. EMBO Rep. 2024 Oct;25(10):4281-4310. doi: 10.1038/s44319-024-00232-4. Epub 2024 Aug 27. PMID: 39191946; PMCID: PMC11467262.
GPX3 supports ovarian cancer tumor progression in vivo and promotes expression of GDF15. Chang C, Cheng YY, Kamlapurkar S, White S, Tang PW, Elhaw AT, Javed Z, Aird KM, Mythreye K, Phaëton R, Hempel N. Gynecol Oncol. 2024 Feb 10;185:8-16. PMID: 38342006. also available on: https://www.biorxiv.org/content/10.1101/2024.01.24.577037v1.full
RNAseq data link: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE254035
Alternative splice variants of the mitochondrial fission protein DNM1L/Drp1 regulate mitochondrial dynamics and cell fate in ovarian cancer. Javed Z, Shin DH, Pan W, White SR, Kim YS, Elhaw AT, Kamlapurkar S, Cheng YY, Benson JC, Abdelnaby AE, Phaëton R, Wang HG, Yang S, Sullivan MLG, St Croix CM, Watkins SC, Mullett SJ, Gelhaus SL, Lee N, Coffman LG, Aird KM, Trebak M, Mythreye K, Walter V, Hempel N. bioRxiv. 2024
Insights into the tumor-stromal-immune cell metabolism cross talk in ovarian cancer. Tang PW, Frisbie L, Hempel N, Coffman L. Am J Physiol Cell Physiol. 2023 Sep 1;325(3):C731-C749.
Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer. Shonibare Z, Monavarian M, O’Connell K, Altomare D, Shelton A, Mehta S, Jaskula-Sztul R, Phaeton R, Starr MD, Whitaker R, Berchuck A, Nixon AB, Arend RC, Lee NY, Miller CR, Hempel N, Mythreye K. Cell Rep. 2022 Jul 26;40(4):111066. PMID: 35905726.
HuR-dependent SOD2 protein synthesis is an early adaptation of ovarian cancer cells in response to anchorage independence. Kim YS, Tang PW, Welles JE, Pan W, Javed Z, Elhaw AT, Mythreye K, Kimball SR, Hempel N. Redox Biology. 2022. 53:102329
Emerging perspectives on growth factor metabolic relationships in the ovarian cancer ascites environment. Monavarian M, Elhaw A, Tang P, Javed Z, Shonibare Z, Scalise CB, Arend R, Jolly MK, Sewell-Loftin MK, Hempel N, Mythreye K. Semin Cancer Biol. 2022 Mar 5:S1044-579X(22)00060-8. PMID: 35259492.
Optimization of Extracellular Flux Assay to Measure Respiration of Anchorage-independent Tumor Cell Spheroids. Javed Z, Worley BL, Stump C, Shimko SS, Crawford LC, Mythreye K, Hempel N. Bio-Protocol 2022 12(40: e4321.
The Mitochondrial Ca2+ uniporter is a central regulator of interorganellar Ca2+ transfer and NFAT activation. Yoast RE, Emrich SM, Zhang X, Xin P, Arige V, Pathak T, Benson JC, Johnson MT, Abdelnaby AE, Lakomski N, Hempel N, Han JM, Dupont G, Yule DI, Sneyd J, Trebak M. J Biol Chem. 2021 Sep 6;297(4):101174. PMID: 34499925
Antisense oligonucleotide-mediated knockdown of Mpzl3 attenuates the negative metabolic effects of diet-induced obesity in mice. Worley BL, Auen T, Arnold AC, Monia BP, Hempel N, Czyzyk TA. Physiol Rep. 2021 May;9(9):e14853. PMID: 33991450
Omnitemporal choreographies of all five STIM/Orai and IP3Rs underlie the complexity of mammalian Ca2+signaling. Emrich SM, Yoast RE, Xin P, Arige V, Wagner LE, Hempel N, Gill DL, Sneyd J, Yule DI, Trebak M. Cell Rep. 2021 Mar 2;34(9):108760. PMID: 33657364
Dichotomous role of the human mitochondrial Na+/Ca2+/Li+ exchanger NCLX in colorectal cancer growth and metastasis. Pathak T, Gueguinou M, Walter V, Delierneux C, Johnson MT, Zhang X, Xin P, Yoast RE, Emrich SM, Yochum GS, Sekler I, Koltun WA, Gill DL, Hempel N, Trebak M. Elife. 2020 Sep 11;9:e59686. PMID: 32914752
Extracellular Glutathione Peroxidase GPx3 and Its Role in Cancer. Chang C, Worley BL, Phaëton R, Hempel N. Cancers. 2020 Aug 6;12(8):2197. PMID: 32781581
Mitochondrial Calcium Regulation of Redox Signaling in Cancer. Delierneux C, Kouba S, Shanmughapriya S, Potier-Cartereau M, Trebak M, Hempel N. Cells. 2020 Feb 12;9(2):432. PMID: 32059571
Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells. Kim YS, Gupta Vallur P, Jones VM, Worley BL, Shimko S, Shin DH, Crawford LC, Chen CW, Aird KM, Abraham T, Shepherd TG, Warrick JI, Lee NY, Phaeton R, Mythreye K, Hempel N. Oncogene. 2020 Feb;39(8):1619-1633. PMID: 31723239
A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction. Zhang X, Pathak T, Yoast R, Emrich S, Xin P, Nwokonko RM, Johnson M, Wu S, Delierneux C, Gueguinou M, Hempel N, Putney JW Jr, Gill DL, Trebak M.Nat Commun. 2019 Apr 29;10(1):1971. PMID: 31036819
Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity. Emrich SM, Yoast RE, Xin P, Zhang X, Pathak T, Nwokonko R, Gueguinou MF, Subedi KP, Zhou Y, Ambudkar IS, Hempel N, Machaca K, Gill DL, Trebak M.J Biol Chem. 2019 Apr 19;294(16):6318-6332. PMID: 30824535
GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment. Worley BL, Kim YS, Mardini J, Zaman R, Leon KE, Vallur PG, Nduwumwami A, Warrick JI, Timmins PF, Kesterson JP, Phaëton R, Lee NY, Walter V, Endres L, Mythreye K, Aird KM, Hempel N. Redox Biol. 2019 Jul;25:101051. PMID: 30509602
TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth. Shah N, Kumar S, Zaman N, Pan CC, Bloodworth JC, Lei W, Streicher JM, Hempel N, Mythreye K, Lee NY. Nat Commun. 2018 Apr 27;9(1):1696. PMID: 29703898
Inhibin Is a Novel Paracrine Factor for Tumor Angiogenesis and Metastasis. Singh P, Jenkins LM, Horst B, Alers V, Pradhan S, Kaur P, Srivastava T, Hempel N, Győrffy B, Broude EV, Lee NY, Mythreye K.Cancer Res. 2018 Jun 1;78(11):2978-2989. Epub 2018 Mar 13.PMID: 29535220
Insights into the Dichotomous Regulation of SOD2 in Cancer. Kim YS, Gupta Vallur P, Phaëton R, Mythreye K, Hempel N.Antioxidants (Basel). 2017 Nov 3;6(4):86.PMID: 29099803
Clonal evolution in paired endometrial intraepithelial neoplasia/atypical hyperplasia and endometrioid adenocarcinoma. Russo M, Broach J, Sheldon K, Houser KR, Liu DJ, Kesterson J, Phaeton R, Hossler C, Hempel N, Baker M, Newell JM, Zaino R, Warrick JI.Hum Pathol. 2017 Sep;67:69-77. doi: 10.1016/j.humpath.2017.07.003. Epub 2017 Jul 14.PMID: 28712776
Cationic dendritic starch as a vehicle for photodynamic therapy and siRNA co-delivery. Engelberth SA, Hempel N, Bergkvist M.J Photochem Photobiol B. 2017 Mar;168:185-192. doi: 10.1016/j.jphotobiol.2017.02.013. Epub 2017 Feb 20.PMID: 28237436
Mitochondria control store-operated Ca2+ entry through Na+ and redox signals. Ben-Kasus Nissim T, Zhang X, Elazar A, Roy S, Stolwijk JA, Zhou Y, Motiani RK, Gueguinou M, Hempel N, Hershfinkel M, Gill DL, Trebak M, Sekler I.EMBO J. 2017 Mar 15;36(6):797-815. doi: 10.15252/embj.201592481. Epub 2017 Feb 20.PMID: 28219928
Crosstalk between calcium and reactive oxygen species signaling in cancer. Hempel N, Trebak M.Cell Calcium. 2017 May;63:70-96. doi: 10.1016/j.ceca.2017.01.007. Epub 2017 Jan 18.PMID: 28143649
Activation of Mitofusin2 by Smad2-RIN1 Complex during Mitochondrial Fusion. Kumar S, Pan CC, Shah N, Wheeler SE, Hoyt KR, Hempel N, Mythreye K, Lee NY.Mol Cell. 2016 May 19;62(4):520-31. doi: 10.1016/j.molcel.2016.04.010. Epub 2016 May 12.PMID: 27184078
Mitochondrial Superoxide Dismutase Has a Protumorigenic Role in Ovarian Clear Cell Carcinoma. Hemachandra LP, Shin DH, Dier U, Iuliano JN, Engelberth SA, Uusitalo LM, Murphy SK, Hempel N.Cancer Res. 2015 Nov 15;75(22):4973-84. doi: 10.1158/0008-5472.CAN-14-3799. Epub 2015 Sep 10.PMID: 26359457
Regulation of MMP-1 expression in response to hypoxia is dependent on the intracellular redox status of metastatic bladder cancer cells. Shin DH, Dier U, Melendez JA, Hempel N.Biochim Biophys Acta. 2015 Dec;1852(12):2593-602. doi: 10.1016/j.bbadis.2015.09.001. Epub 2015 Sep 5.PMID: 26343184
Chemically Modified Dendritic Starch: A Novel Nanomaterial for siRNA Delivery. Engelberth SA, Hempel N, Bergkvist M.Bioconjug Chem. 2015 Aug 19;26(8):1766-74. doi: 10.1021/acs.bioconjchem.5b00313. Epub 2015 Aug 11.PMID: 26218732
Metastatic bladder cancer cells distinctively sense and respond to physical cues of collagen fibril-mimetic nanotopography. Iuliano JN, Kutscha PD, Biderman NJ, Subbaram S, Groves TR, Tenenbaum SA, Hempel N.Exp Biol Med (Maywood). 2015 May;240(5):601-10. doi: 10.1177/1535370214560973. Epub 2014 Dec 2.PMID: 25465204
Development of nanoscale approaches for ovarian cancer therapeutics and diagnostics. Engelberth SA, Hempel N, Bergkvist M.Crit Rev Oncog. 2014;19(3-4):281-315. doi: 10.1615/critrevoncog.2014011455.PMID: 25271436
Bioenergetic analysis of ovarian cancer cell lines: profiling of histological subtypes and identification of a mitochondria-defective cell line. Dier U, Shin DH, Hemachandra LP, Uusitalo LM, Hempel N.PLoS One. 2014 May 23;9(5):e98479. doi: 10.1371/journal.pone.0098479. eCollection 2014.PMID: 24858344
Intracellular redox status controls membrane localization of pro- and anti-migratory signaling molecules. Hempel N, Melendez JA.Redox Biol. 2014 Jan 20;2:245-50. doi: 10.1016/j.redox.2014.01.005. eCollection 2014.PMID: 24494199
Acquisition of the metastatic phenotype is accompanied by H2O2-dependent activation of the p130Cas signaling complex. Hempel N, Bartling TR, Mian B, Melendez JA.Mol Cancer Res. 2013 Mar;11(3):303-12. PMID: 23345605
Recent advances in intracellular and in vivo ROS sensing: focus on nanoparticle and nanotube applications. Uusitalo LM, Hempel N.Int J Mol Sci. 2012;13(9):10660-79. PMID: 23109815
Hempel Lab 