Publications

Recent selected publications shown. For a complete list see Google Scholar

Preprints

Reciprocal epigenetic Sox2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer. ZAINAB SHONIBARE, Mehri Monavarian, Kathleen O’Connell, Diego Altomare, Abigail K Shelton, Shubham Mehta, Renata Jaskula-Sztul, Rebecca Phaeton, Mark D Starr, Regina Whitaker, Andrew Berchuck, Andrew Nixon, Rebecca C Arend, Nam Y Lee, C Ryan Miller, Nadine Hempel, Karthikeyan Mythreye (2022). bioRxiv 2022.01.11.475900.

2022

HuR-dependent SOD2 protein synthesis is an early adaptation of ovarian cancer cells in response to anchorage independence. Kim YS, Tang PW, Welles JE, Pan W, Javed Z, Elhaw AT, Mythreye K, Kimball SR, Hempel N. Redox Biology 53:102329

Emerging perspectives on growth factor metabolic relationships in the ovarian cancer ascites environment. Monavarian M, Elhaw A, Tang P, Javed Z, Shonibare Z, Scalise CB, Arend R, Jolly MK, Sewell-Loftin MK, Hempel N, Mythreye K. Semin Cancer Biol. 2022 Mar 5:S1044-579X(22)00060-8. doi: 10.1016/j.semcancer.2022.03.004. PMID: 35259492.

Optimization of Extracellular Flux Assay to Measure Respiration of Anchorage-independent Tumor Cell Spheroids. Javed Z, Worley BL, Stump C, Shimko SS, Crawford LC, Mythreye K, Hempel N. Bio-Protocol 2022 12(40: e4321.

2021

The Mitochondrial Ca2+ uniporter is a central regulator of interorganellar Ca2+ transfer and NFAT activation. Yoast RE, Emrich SM, Zhang X, Xin P, Arige V, Pathak T, Benson JC, Johnson MT, Abdelnaby AE, Lakomski N, Hempel N, Han JM, Dupont G, Yule DI, Sneyd J, Trebak M. J Biol Chem. 2021 Sep 6;297(4):101174. PMID: 34499925

Antisense oligonucleotide-mediated knockdown of Mpzl3 attenuates the negative metabolic effects of diet-induced obesity in mice. Worley BL, Auen T, Arnold AC, Monia BP, Hempel N, Czyzyk TA. Physiol Rep. 2021 May;9(9):e14853. PMID: 33991450 

Omnitemporal choreographies of all five STIM/Orai and IP3Rs underlie the complexity of mammalian Ca2+signaling. Emrich SM, Yoast RE, Xin P, Arige V, Wagner LE, Hempel N, Gill DL, Sneyd J, Yule DI, Trebak M. Cell Rep. 2021 Mar 2;34(9):108760. PMID: 33657364

2020

Dichotomous role of the human mitochondrial Na+/Ca2+/Li+ exchanger NCLX in colorectal cancer growth and metastasis. Pathak T, Gueguinou M, Walter V, Delierneux C, Johnson MT, Zhang X, Xin P, Yoast RE, Emrich SM, Yochum GS, Sekler I, Koltun WA, Gill DL, Hempel N, Trebak M. Elife. 2020 Sep 11;9:e59686. PMID: 32914752

Extracellular Glutathione Peroxidase GPx3 and Its Role in Cancer. Chang C, Worley BL, Phaëton R, Hempel N. Cancers. 2020 Aug 6;12(8):2197. PMID: 32781581

Mitochondrial Calcium Regulation of Redox Signaling in Cancer. Delierneux C, Kouba S, Shanmughapriya S, Potier-Cartereau M, Trebak M, Hempel N. Cells. 2020 Feb 12;9(2):432. PMID: 32059571

Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells. Kim YS, Gupta Vallur P, Jones VM, Worley BL, Shimko S, Shin DH, Crawford LC, Chen CW, Aird KM, Abraham T, Shepherd TG, Warrick JI, Lee NY, Phaeton R, Mythreye K, Hempel N. Oncogene. 2020 Feb;39(8):1619-1633. PMID: 31723239

2019

A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction. Zhang X, Pathak T, Yoast R, Emrich S, Xin P, Nwokonko RM, Johnson M, Wu S, Delierneux C, Gueguinou M, Hempel N, Putney JW Jr, Gill DL, Trebak M.Nat Commun. 2019 Apr 29;10(1):1971. PMID: 31036819

Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity. Emrich SM, Yoast RE, Xin P, Zhang X, Pathak T, Nwokonko R, Gueguinou MF, Subedi KP, Zhou Y, Ambudkar IS, Hempel N, Machaca K, Gill DL, Trebak M.J Biol Chem. 2019 Apr 19;294(16):6318-6332. PMID: 30824535

GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment. Worley BL, Kim YS, Mardini J, Zaman R, Leon KE, Vallur PG, Nduwumwami A, Warrick JI, Timmins PF, Kesterson JP, Phaëton R, Lee NY, Walter V, Endres L, Mythreye K, Aird KM, Hempel N. Redox Biol. 2019 Jul;25:101051. PMID: 30509602

2018

TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth. Shah N, Kumar S, Zaman N, Pan CC, Bloodworth JC, Lei W, Streicher JM, Hempel N, Mythreye K, Lee NY. Nat Commun. 2018 Apr 27;9(1):1696. PMID: 29703898

Inhibin Is a Novel Paracrine Factor for Tumor Angiogenesis and Metastasis. Singh P, Jenkins LM, Horst B, Alers V, Pradhan S, Kaur P, Srivastava T, Hempel N, Győrffy B, Broude EV, Lee NY, Mythreye K.Cancer Res. 2018 Jun 1;78(11):2978-2989. Epub 2018 Mar 13.PMID: 29535220

2017

Insights into the Dichotomous Regulation of SOD2 in Cancer. Kim YS, Gupta Vallur P, Phaëton R, Mythreye K, Hempel N.Antioxidants (Basel). 2017 Nov 3;6(4):86.PMID: 29099803

Clonal evolution in paired endometrial intraepithelial neoplasia/atypical hyperplasia and endometrioid adenocarcinoma. Russo M, Broach J, Sheldon K, Houser KR, Liu DJ, Kesterson J, Phaeton R, Hossler C, Hempel N, Baker M, Newell JM, Zaino R, Warrick JI.Hum Pathol. 2017 Sep;67:69-77. doi: 10.1016/j.humpath.2017.07.003. Epub 2017 Jul 14.PMID: 28712776

Cationic dendritic starch as a vehicle for photodynamic therapy and siRNA co-delivery. Engelberth SA, Hempel N, Bergkvist M.J Photochem Photobiol B. 2017 Mar;168:185-192. doi: 10.1016/j.jphotobiol.2017.02.013. Epub 2017 Feb 20.PMID: 28237436

Mitochondria control store-operated Ca2+ entry through Na+ and redox signals. Ben-Kasus Nissim T, Zhang X, Elazar A, Roy S, Stolwijk JA, Zhou Y, Motiani RK, Gueguinou M, Hempel N, Hershfinkel M, Gill DL, Trebak M, Sekler I.EMBO J. 2017 Mar 15;36(6):797-815. doi: 10.15252/embj.201592481. Epub 2017 Feb 20.PMID: 28219928

Crosstalk between calcium and reactive oxygen species signaling in cancerHempel N, Trebak M.Cell Calcium. 2017 May;63:70-96. doi: 10.1016/j.ceca.2017.01.007. Epub 2017 Jan 18.PMID: 28143649

2016

Activation of Mitofusin2 by Smad2-RIN1 Complex during Mitochondrial Fusion. Kumar S, Pan CC, Shah N, Wheeler SE, Hoyt KR, Hempel N, Mythreye K, Lee NY.Mol Cell. 2016 May 19;62(4):520-31. doi: 10.1016/j.molcel.2016.04.010. Epub 2016 May 12.PMID: 27184078 

2015

Mitochondrial Superoxide Dismutase Has a Protumorigenic Role in Ovarian Clear Cell Carcinoma. Hemachandra LP, Shin DH, Dier U, Iuliano JN, Engelberth SA, Uusitalo LM, Murphy SK, Hempel N.Cancer Res. 2015 Nov 15;75(22):4973-84. doi: 10.1158/0008-5472.CAN-14-3799. Epub 2015 Sep 10.PMID: 26359457

Regulation of MMP-1 expression in response to hypoxia is dependent on the intracellular redox status of metastatic bladder cancer cells. Shin DH, Dier U, Melendez JA, Hempel N.Biochim Biophys Acta. 2015 Dec;1852(12):2593-602. doi: 10.1016/j.bbadis.2015.09.001. Epub 2015 Sep 5.PMID: 26343184 

Chemically Modified Dendritic Starch: A Novel Nanomaterial for siRNA Delivery. Engelberth SA, Hempel N, Bergkvist M.Bioconjug Chem. 2015 Aug 19;26(8):1766-74. doi: 10.1021/acs.bioconjchem.5b00313. Epub 2015 Aug 11.PMID: 26218732

Metastatic bladder cancer cells distinctively sense and respond to physical cues of collagen fibril-mimetic nanotopography. Iuliano JN, Kutscha PD, Biderman NJ, Subbaram S, Groves TR, Tenenbaum SA, Hempel N.Exp Biol Med (Maywood). 2015 May;240(5):601-10. doi: 10.1177/1535370214560973. Epub 2014 Dec 2.PMID: 25465204

2014

Development of nanoscale approaches for ovarian cancer therapeutics and diagnostics. Engelberth SA, Hempel N, Bergkvist M.Crit Rev Oncog. 2014;19(3-4):281-315. doi: 10.1615/critrevoncog.2014011455.PMID: 25271436

Bioenergetic analysis of ovarian cancer cell lines: profiling of histological subtypes and identification of a mitochondria-defective cell line. Dier U, Shin DH, Hemachandra LP, Uusitalo LM, Hempel N.PLoS One. 2014 May 23;9(5):e98479. doi: 10.1371/journal.pone.0098479. eCollection 2014.PMID: 24858344 

Intracellular redox status controls membrane localization of pro- and anti-migratory signaling molecules. Hempel N, Melendez JA.Redox Biol. 2014 Jan 20;2:245-50. doi: 10.1016/j.redox.2014.01.005. eCollection 2014.PMID: 24494199

2013

Acquisition of the metastatic phenotype is accompanied by H2O2-dependent activation of the p130Cas signaling complex. Hempel N, Bartling TR, Mian B, Melendez JA.Mol Cancer Res. 2013 Mar;11(3):303-12. PMID: 23345605

Recent advances in intracellular and in vivo ROS sensing: focus on nanoparticle and nanotube applications. Uusitalo LM, Hempel N.Int J Mol Sci. 2012;13(9):10660-79. PMID: 23109815